Discoveries

 

Scientific Discoveries using Brain Bank tissue

The Queensland Brain Bank tissue has been played a critical role in our understanding of how neurodegenerative diseases, such as Alzheimer’s, affect the degradation of specific parts of the brain. The brain bank tissue has resulted in a large number of discoveries including the identification a important differences in the function of a variety of genes and proteins. These are important steps that are required to uncover the underlying mechanisms that result in the onset of neurodegenerative diseases and are laying the foundations for the development of new treatments aimed at preventing progression of the disease or preventing its initiation.

The QBB has been operating since the early 1990’s. Since then, researchers using the tissue stored in the Brain Bank have written many scientific articles: the author, title, journal name, and journal entry of some of these articles is given below. If you want to read the articles, try searching for the journal name (located after the article title) on an Internet search engine.

1. Scott, H.A., et al., Glutamate transporter variants reduce glutamate uptake in Alzheimer’s disease. Neurobiology of Aging, 2011. 32(3): p. 553.e1-553.e11.
2. Proctor, D.T., E.J. Coulson, and P.R. Dodd, Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer’s disease. Progress in Neurobiology, 2011. 93(4): p. 509-521.
3. Mackay, R.K., et al., Differential expression of 14-3-3 isoforms in human alcoholic brain. Alcoholism: Clinical and Experimental Research, 2011. 35(6): p. 1041-1049.
4. Kuo, S.-W. and P.R. Dodd, Electrically evoked synaptosomal amino acid transmitter release in human brain in alcohol misuse. Neurosignals, 2011(in press).
5. Etheridge, N., et al., Identifying changes in the synaptic proteome of cirrhotic alcoholic superior frontal gyrus. Current Neuropharmacology, 2011. 9(2): p. 122-128.
6. Renshaw, G.M.C., G. Wise, and P.R. Dodd, Ecophysiology of neuronal metabolism in transiently oxygen-depleted environments: Evidence that GABA is accumulated pre-synaptically in the cerebellum. Comparative Biochemistry and Physiology – A Molecular and Integrative Physiology, 2010. 155(4): p. 486-492.
7. Proctor, D.T., E.J. Coulson, and P.R. Dodd, Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology. Journal of Alzheimer’s Disease, 2010. 21(3): p. 795-811.
8. Ho, A.M.C., et al., Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics. Brain Research, 2010. 1340(C): p. 1-9.
9. Gebhardt, F.M., H.A. Scott, and P.R. Dodd, Housekeepers for accurate transcript expression analysis in Alzheimer’s disease autopsy brain tissue. Alzheimer’s and Dementia, 2010. 6(6): p. 465-474.
10. Gebhardt, F.M., et al., Exon-skipping Splice Variants of Excitatory Amino Acid Transporter-2 (EAAT2) Form Heteromeric Complexes with Full-length EAAT2. Journal of Biological Chemistry, 2010. 285(41): p. 31313-31324.
11. Daglish, M.R.C., et al., Impulsive Personality Predicts Risky Sexual Behaviour in Heroin Addicts. Journal of Psychopharmacology, 2010. 24: p. A27-A27.
12. Ridge, J.P., A.M.C. Ho, and P.R. Dodd, Sex Differences in NMDA Receptor Expression in Human Alcoholics. Alcohol and Alcoholism, 2009. 44(6): p. 594-601.
13. Kaewsuk, S., et al., Regional Expression of Dopamine D1 and D2 Receptor Proteins in the Cerebral Cortex of Asphyxic Newborn Infants. Journal of Child Neurology, 2009. 24(2): p. 183-193.
14. Etheridge, N., et al., The effects of alcohol on the brain, in Encyclopaedia of Neuroscience, U. Windhorst, M.D. Binder, and N. Hirokawa, Editors. 2009, Springer: Heidelberg.
15. Etheridge, N., et al., Identifying changes in the alcoholic synaptic proteome, in Alcoholism-Clinical and Experimental Research. 2009, WILEY-BLACKWELL PUBLISHING, INC: San Diego, California, USA. p. 18A.
16. Etheridge, N., et al., Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain. Proteomics. Clinical Applications, 2009. 3(6): p. 730-742.
17. Dissabandara, L.O., et al., Patterns of substance use in male incarcerated drug users in Sri Lanka. Drug and Alcohol Review, 2009. 28(6): p. 600-607.
18. Ridge, J.P., et al., The Expression of NMDA Receptor Subunit mRNA in Human Chronic Alcoholics Influence of Cirrhosis and Genotype. Annals of the New York Academy of Sciences, 2008. 1139: p. 10-19.
19. Ridge, J.P., et al. The Expression of NMDA Receptor Subunit mRNA in Human Chronic Alcoholics Influence of Cirrhosis and Genotype. 2008.
20. De Silva, K.R.D., S.K. Shankar, and P.R. Dodd, A brain bank for Sri Lanka. Ceylon Medical Journal, 2008. 53(4): p. 139-140.
21. Al-Housseini, A.M., et al., Upregulation of beta-catenin levels in superior frontal cortex of chronic alcoholics. Alcoholism-Clinical and Experimental Research, 2008. 32(6): p. 1080-1090.
22. Agarwal, S., R.K. Tannenberg, and P.R. Dodd, Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer’s disease. Journal of Alzheimer’s Disease, 2008. 14(3): p. 313-321.
23. Walton, H.S., et al., Analysis of multiple exon-skipping mRNA splice variants using SYBR Green real-time RT-PCR. Journal of Neuroscience Methods, 2007. 160(2): p. 294-301.
24. Walton, H.S. and P.R. Dodd, Glutamate-glutamine cycling in Alzheimer’s disease. Neurochemistry International, 2007. 50(7-8): p. 1052-1066.
25. Liu, J., et al., Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics. Alcoholism-Clinical and Experimental Research, 2007. 31(9): p. 1460-1466.
26. Etheridge, N., et al. Proteomic analysis of neurodegeneration in the alcoholic brain. in Alcoholism-Clinical and Experimental Research. 2007. Chicago, Illinois, USA: WILEY-BLACKWELL PUBLISHING, INC.
27. Tannenberg, R.K., et al., Selective loss of synaptic proteins in Alzheimer’s disease: Evidence for an increased severity with APOE ?4. Neurochemistry International, 2006. 49(7): p. 631-639.
28. Ragnarsson, L., et al., NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G. Journal of Neurochemistry, 2006. 96(1): p. 283-291.
29. Liu, J.W., et al., Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology, 2006. 31(7): p. 1574-1582.
30. Lewohl, J.M., et al., Genomic and proteomic analysis of synaptic protein expression in the brains of human alcoholics. Alcoholism-Clinical and Experimental Research, 2006. 30(9): p. 76A-76A.
31. Dodd, P.R., et al., Latest developments in the microarray analysis of human brain mRNA. Journal of Neurochemistry, 2006. 98: p. 50-50.
32. Dodd, P.R., et al., Genes and gene expression in the brains of human alcoholics. Annals of the New York Academy of Sciences, 2006. 1074(Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, Ghb, and Substituted Amphetamines): p. 104-115.
33. Buckley, S.T., et al., GABAA receptor beta isoform protein expression in human alcoholic brain: interaction with genotype. Neurochemistry International, 2006. 49(6): p. 557-567.
34. Williams, S.M., et al., Glial glutamate transporter expression patterns in brains from multiple mammalian species. GLIA, 2005. 49(4): p. 520-541.
35. Tsai, V.W.W., P.R. Dodd, and R.J. Lewis, The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor. Neuroscience, 2005. 130(2): p. 457-467.
36. Tsai, V.W., et al., The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer’s disease. Neurotoxicity research, 2005. 7(1-2): p. 125-141.
37. Pow, D.V., et al., Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans. Cell and Tissue Research, 2005. 320(3): p. 379-392.
38. Liu, J., et al., Distinct patterns of gene expression in human frontal cortex of cirrhotic alcoholics. Alcoholism-Clinical and Experimental Research, 2005. 29(5): p. 91A-91A.
39. Lewohl, J.M., et al., Expression of MBP, PLP, MAG, CNP, and GFAP in the human alcoholic brain. Alcoholism-Clinical and Experimental Research, 2005. 29(9): p. 1698-1705.
40. Harper, C., et al., The pathophysiology of ‘brain shrinkage’ in alcoholics – Structural and molecular changes and clinical implications. Alcoholism-Clinical and Experimental Research, 2005. 29(6): p. 1106-1115.
41. Crews, F.T., et al., Alcoholic neurobiology: changes in dependence and recovery. Alcoholism-Clinical and Experimental Research, 2005. 29(8): p. 1504-1513.
42. Bergeson, S.E., et al., Expression profiling in alcoholism research. Alcoholism-Clinical and Experimental Research, 2005. 29(6): p. 1066-1073.
43. Wixey, J.A., P.R. Dodd, and J.M. Lewohl, RGS protein expression in the human alcoholic brain: Effects of gender. Alcoholism-Clinical and Experimental Research, 2004. 28(5): p. 51A-51A.
44. Tannenberg, R.K., et al., The identification and characterization of excitotoxic nerve-endings in Alzheimer disease. Current Alzheimer Research, 2004. 1(1): p. 11-25.
45. Liu, J.W., et al., Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. Journal of Neurochemistry, 2004. 90(5): p. 1050-1058.
46. Liu, J., et al., Distinct patterns of gene expression in human frontal cortex discriminate alcoholic from nonalcoholic individuals. Alcoholism-Clinical and Experimental Research, 2004. 28(5): p. 7A-7A.
47. Lewohl, J.M., J.A. Wixey, and P.R. Dodd, Gender differences in the expression of myelin related proteins in human alcoholic. Alcoholism-Clinical and Experimental Research, 2004. 28(5): p. 120A-120A.
48. Lewohl, J.M., et al., The application of proteomics to the human alcoholic brain. Annals of the New York Academy of Sciences, 2004. 1025: p. 14-26.
49. Hynd, M.R., H.L. Scott, and P.R. Dodd, Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer’s disease. Journal of Neurochemistry, 2004. 89(1): p. 240-247.
50. Hynd, M.R., H.L. Scott, and P.R. Dodd, Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer’s disease. Journal of Neurochemistry, 2004. 90(4): p. 913-919.
51. Hynd, M.R., H.L. Scott, and P.R. Dodd, Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s disease. Neurochemistry International, 2004. 45(5): p. 583-595.
52. Foley, P.F., et al. Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. 2004.
53. Dodd, P.R. and J.M. Lewohl, Microarray and proteomic analysis of the human alcoholic brain. Alcoholism-Clinical and Experimental Research, 2004. 28(8): p. 54A-54A.
54. Dodd, P.R., et al., Genes and gene expression in the brain of the alcoholic. Addictive Behaviors, 2004. 29(7): p. 1295-309.
55. Buckley, S.T. and P.R. Dodd, GABAA receptor β subunit mRNA expression in the human alcoholic brain. Neurochemistry International, 2004. 45(7): p. 1011-1020.